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Viennese researchers discover novel approach to combat epilepsy seizures!
The Medical University of Vienna is researching a new therapeutic approach against epilepsy in order to understand the causes of seizures.
Viennese researchers discover novel approach to combat epilepsy seizures!
A new approach to epilepsy research brings a breath of fresh air to the treatment of this widespread disease. Around 65 million people worldwide suffer from epilepsy, a disease caused by a disruption in the control of excitation in brain cells. In a recent study, the Medical University of Vienna has discovered a molecular mechanism that could play a crucial role in the development of epileptic seizures. This mechanism, known as “paroxysmal depolarization bursts” (PDS), is characterized by increased electrical activity in nerve cells and is considered a precursor to seizures. As the [Medical University of Vienna](https://www.meduniwien.ac.at/web/ueber-uns/news/2025/news-im-juni-2025/epilepsie-neuer-konzept-fuer-ursaechliche-therapie-erforscht/medizin- Wissenschaft/) reports, confirms the hypothesis that PDS also play a central role in the development of the disease.
The findings of the study show that PDS occur particularly in the context of brain damage such as after a stroke or traumatic brain injury and activate a protective mechanism in the hippocampus in the short term, which can, however, lead to seizure-like electrical discharges in the long term. Until now, epilepsy attacks have mainly been treated symptomatically in order to suppress them. However, with new information from the study published in the Journal of Neuroscience, it may be possible to develop preventive treatments for specific forms of epilepsy. According to the Medical University of Vienna, further studies are already being planned to advance fundamental therapies.
A look behind the scenes of research
The Epilepsy Working Group, led by Prof. Dr. med. J. Rémi, is concerned with improving the diagnosis, therapy and prognosis assessment of epilepsy. In addition to PDS, the research focus is also on semiological analysis and electroencephalography (EEG) in order to better classify and understand the different types of seizures. This is crucial for the diagnosis and localization of seizure origin zones in focal epilepsies.
A further drive for innovation is evident in the use of the latest technologies, such as 3D processes and AI methods for analyzing seizures. These approaches, according to the LMU Klinikum, help to understand and improve the effects of epilepsy on patients' quality of life. The combination of state-of-the-art technology and sound basic research forms a promising basis for future developments in the therapy of this chronic neurological disease.
Further research will therefore be crucial to not only treat the symptoms of epilepsy, but also to sustainably combat the causes. The light at the end of the tunnel for many of those affected could become more tangible thanks to these new scientific findings.